$65.00
Melanotan 2 is a synthetic cyclic heptapeptide (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂) that acts as a potent, nonselective agonist of melanocortin receptors. It is widely utilized in laboratory research focused on receptor binding affinity, intracellular signal transduction, and melanocortin receptor-mediated cAMP activation across MC1R through MC5R. MT-II is commonly applied as a research model for studying GPCR signaling behavior, receptor desensitization processes, and neuroendocrine peptide-receptor interactions.
For research use only. Not for human consumption.
References:
Hadley ME et al., Peptides, 1996; 17(4):593-596
Mountjoy KG et al., Endocrine Reviews, 1994; 15(2):135-155
Hruby VJ et al., Peptides, 2000; 21(3):423-438
Melanotan 2 (MT-2) is a synthetic cyclic heptapeptide designed for laboratory research involving melanocortin receptor signaling. It functions as a nonselective agonist across multiple melanocortin receptors and is commonly used as a research model for studying peptide-receptor interactions and neuroendocrine signaling mechanisms.
Biochemical Characteristics
Melanotan 2 consists of a cyclic peptide structure that provides enhanced stability and receptor affinity. Its molecular design allows interaction with melanocortin receptors MC1R through MC5R, leading to downstream intracellular signaling activity. The cyclic conformation contributes to resistance against enzymatic degradation, making MT-2 suitable for controlled biochemical and receptor-binding studies.
Research Applications
MT-2 is widely utilized in laboratory research focused on melanocortin receptor pharmacology, GPCR signaling behavior, and intracellular cAMP activation. It is applied in studies examining receptor binding affinity, signal transduction pathways, and receptor desensitization dynamics within melanocortin systems.
Pathway / Mechanistic Context
Mechanistic studies involving Melanotan 2 explore its role in melanocortin-mediated signaling cascades, particularly GPCR-driven cAMP production. Research focuses on receptor activation, intracellular second messenger regulation, and feedback mechanisms influencing receptor sensitivity and signaling duration.
Preclinical Research Summary
Preclinical investigations have examined Melanotan 2 in various in vitro and animal research models to evaluate melanocortin receptor activation and signaling outcomes. These studies support its continued use as a research tool for understanding melanocortin system regulation and neuroendocrine peptide behavior.
Form & Analytical Testing
Melanotan 2 is supplied as a lyophilized peptide and undergoes analytical testing, including HPLC, to verify purity and composition. Analytical validation ensures consistency and suitability for research applications requiring precise peptide characterization.
RUO Disclaimer
This product is intended for research and laboratory use only. It is not approved for human consumption, medical treatment, veterinary use, cosmetic application, or diagnostic purposes. Handling should be performed only by qualified professionals trained in proper laboratory procedures.
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