Description

LL-37 is a synthetic antimicrobial peptide derived from the human cathelicidin family. It is widely studied in laboratory research focused on innate immune mechanisms, peptide–membrane interactions, and immunomodulatory signaling pathways.

Biochemical Characteristics

LL-37 is a cationic amphipathic peptide composed of 37 amino acids. Its structure enables interaction with lipid membranes and cellular receptors, supporting studies related to membrane permeability, host defense peptide activity, and immune signaling modulation.

Research Applications

LL-37 is utilized in research models investigating antimicrobial peptide function, inflammatory signaling, chemotactic responses, and cytokine regulation. It is commonly applied in studies focused on host defense mechanisms and cellular immune communication.

Pathway / Mechanistic Context

Mechanistic studies examine LL-37’s interaction with microbial membranes, toll-like receptor pathways, and intracellular signaling cascades associated with immune activation and inflammatory response regulation.

Preclinical Research Summary

Preclinical research has evaluated LL-37 in in vitro and experimental models to explore antimicrobial peptide behavior, immune pathway modulation, and peptide-mediated cellular signaling processes.

Form & Analytical Testing

LL-37 is supplied as a lyophilized peptide and undergoes analytical testing, including HPLC verification, to confirm identity, purity, and consistency for laboratory research use.

RUO Disclaimer

This product is intended strictly for research and laboratory use only. It is not approved for human consumption, medical treatment, veterinary use, cosmetic application, or diagnostic purposes. Handling should be performed only by qualified professionals trained in proper laboratory procedures.