Description

IGF-1 LR3 is a synthetic long-acting analog of insulin-like growth factor-1 developed for laboratory research focused on growth factor signaling and receptor-mediated cellular pathways. It serves as a research tool for examining IGF-1 receptor activation and downstream signaling mechanisms.

Biochemical Characteristics

IGF-1 LR3 contains an arginine substitution at position 3 and an extended N-terminal sequence that enhances stability and reduces binding to IGF-binding proteins in experimental systems. This structural modification supports sustained receptor interaction and intracellular signaling activation under controlled conditions.

Research Applications

IGF-1 LR3 is utilized in research models investigating IGF-1 receptor pharmacology, cellular growth signaling, metabolic pathway modulation, and growth factor–mediated intracellular responses.

Pathway / Mechanistic Context

Mechanistic studies focus on IGF-1 LR3 interaction with IGF-1R and subsequent activation of PI3K/Akt and MAPK signaling cascades. Research evaluates cellular signaling dynamics, receptor phosphorylation events, and downstream transcriptional responses.

Preclinical Research Summary

Preclinical investigations have examined IGF-1 LR3 in in vitro and experimental models to better understand growth factor signaling and receptor-mediated pathway regulation.

Form & Analytical Testing

IGF-1 LR3 is supplied as a lyophilized peptide and undergoes analytical verification, including HPLC testing, to confirm identity, purity, and consistency for laboratory research use.

RUO Disclaimer

This product is intended strictly for research and laboratory use only. It is not approved for human consumption, medical treatment, veterinary use, cosmetic application, or diagnostic purposes. Handling should be performed only by qualified professionals trained in proper laboratory procedures.