Description

Follistatin-344 is a recombinant isoform of the endogenous follistatin protein and is widely studied in laboratory research focused on growth factor signaling and TGF-β pathway regulation. It serves as a research tool for examining activin and myostatin-binding dynamics in experimental systems.

Biochemical Characteristics

Follistatin-344 is a glycoprotein that binds to activins and other TGF-β family ligands, preventing receptor interaction and downstream signaling. Its structure enables high-affinity ligand binding and modulation of growth-related signaling cascades in controlled research environments.

Research Applications

Follistatin-344 is utilized in studies investigating activin inhibition, myostatin pathway modulation, and cellular growth regulation. It is applied in experimental models examining muscle-related signaling, cellular differentiation, and endocrine growth factor pathways.

Pathway / Mechanistic Context

Mechanistic research focuses on Follistatin-344 binding to activins and myostatin, thereby limiting ligand interaction with TGF-β receptors. Studies evaluate downstream SMAD signaling modulation and regulatory effects on growth-associated pathways under laboratory conditions.

Preclinical Research Summary

Preclinical investigations have examined Follistatin-344 in in vitro and experimental models to better understand TGF-β superfamily regulation and growth signaling modulation.

Form & Analytical Testing

Follistatin-344 is supplied as a lyophilized recombinant protein and undergoes analytical verification to confirm identity, purity, and structural integrity for research use.

RUO Disclaimer

This product is intended strictly for research and laboratory use only. It is not approved for human consumption, medical treatment, veterinary use, cosmetic application, or diagnostic purposes. Handling should be performed only by qualified professionals trained in proper laboratory procedures.