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Tesamorelin is a stabilized synthetic analog of growth hormone-releasing hormone (GHRH 1-44) featuring a trans-3-hexenoic acid modification at position 2 to enhance peptide stability. In research settings, it binds to GHRH receptors and is studied for its effects on growth hormone synthesis and secretion. Tesamorelin is commonly used in endocrine and metabolic research to investigate receptor binding dynamics, peptide stability, and modulation of the somatotropic axis.
For research use only. Not for human consumption.
References:
Falutz J et al., Annals of Internal Medicine, 2010; 152(5):323-331
Gelato MC et al., Journal of Clinical Endocrinology & Metabolism, 2005; 90(9):5247-5253
Stanley TL et al., Journal of Clinical Endocrinology & Metabolism, 2014; 99(3):E449-E458
Tesamorelin is a stabilized synthetic analog of growth hormone-releasing hormone (GHRH 1-44) developed for laboratory research involving endocrine signaling pathways. It is designed to bind GHRH receptors and is commonly studied in experimental settings focused on growth hormone regulation and somatotropic axis activity.
Biochemical Characteristics
Tesamorelin incorporates a trans-3-hexenoic acid modification at position 2, enhancing peptide stability and resistance to enzymatic degradation. This structural modification allows sustained receptor interaction while maintaining affinity for GHRH receptors. Its peptide sequence supports controlled biochemical studies examining hormone release signaling and receptor kinetics.
Research Applications
Tesamorelin is widely used in laboratory research exploring growth hormone regulation, peptide stability, and receptor-mediated endocrine signaling. It is applied in studies evaluating hormone release mechanisms, feedback regulation within the somatotropic axis, and peptide-receptor binding behavior in controlled experimental models.
Pathway / Mechanistic Context
Mechanistic research involving Tesamorelin focuses on GHRH receptor activation and downstream signaling pathways regulating growth hormone synthesis and secretion. Studies examine intracellular signaling cascades, feedback control systems, and interactions within endocrine regulatory networks influenced by GHRH analog activity.
Preclinical Research Summary
Preclinical investigations have evaluated Tesamorelin in in vitro and animal research models to better understand its role in growth hormone modulation and endocrine signaling dynamics. These studies support its use as a research tool for examining hormone regulation and peptide stability under experimental conditions.
Form & Analytical Testing
Tesamorelin is supplied as a lyophilized peptide and undergoes analytical testing, including HPLC, to verify purity, identity, and consistency. Analytical validation ensures suitability for research applications requiring precise peptide characterization.
RUO Disclaimer
This product is intended for research and laboratory use only. It is not approved for human consumption, medical treatment, veterinary use, cosmetic application, or diagnostic purposes. Handling should be performed only by qualified professionals trained in proper laboratory procedures.
| Strength | 5 mg, 10 mg, 15 mg |
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