$95.00
IGF-1 DES (1–3) is a truncated analog of insulin-like growth factor-1 lacking the first three N-terminal amino acids and studied for its interaction with the IGF-1 receptor (IGF-1R) in experimental models. It is investigated for its enhanced receptor binding affinity and reduced interaction with IGF-binding proteins. Preclinical research utilizes IGF-1 DES to examine receptor activation kinetics, PI3K/Akt and MAPK signaling cascades, and growth factor–mediated cellular signaling under controlled laboratory conditions.
For research use only. Not for human consumption.
References:
Bagley CJ et al., Biochem J, 1989
Le Roith D et al., Endocr Rev, 2001
Jones JI et al., Endocr Rev, 1995
IGF-1 DES (1–3) is a modified insulin-like growth factor-1 analog widely studied in laboratory research focused on receptor-mediated growth signaling and cellular pathway activation. It serves as a research tool for examining IGF-1 receptor dynamics.
Biochemical Characteristics
IGF-1 DES is structurally derived from endogenous IGF-1 but lacks the first three amino acids, reducing affinity for IGF-binding proteins and enhancing receptor interaction in experimental systems. Its structure supports investigation of receptor binding and intracellular signaling activity.
Research Applications
IGF-1 DES is utilized in research models investigating IGF-1 receptor pharmacology, cellular growth signaling, peptide stability, and downstream pathway activation under controlled laboratory conditions.
Pathway / Mechanistic Context
Mechanistic research focuses on IGF-1 DES interaction with IGF-1R and activation of PI3K/Akt and MAPK signaling pathways influencing cellular proliferation and metabolic regulation mechanisms.
Preclinical Research Summary
Preclinical investigations have evaluated IGF-1 DES in in vitro and experimental models to better understand receptor-mediated growth factor signaling and intracellular pathway modulation.
Form & Analytical Testing
IGF-1 DES is supplied as a lyophilized peptide and undergoes analytical verification, including HPLC testing, to confirm identity, purity, and composition consistency for laboratory research use.
RUO Disclaimer
This product is intended strictly for research and laboratory use only. It is not approved for human consumption, medical treatment, veterinary use, cosmetic application, or diagnostic purposes. Handling should be performed only by qualified professionals trained in proper laboratory procedures.
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